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Cake day: July 1st, 2023

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  • Abstract

    High protein intake is common in western societies and is often promoted as part of a healthy lifestyle; however, amino-acid-mediated mammalian target of rapamycin (mTOR) signalling in macrophages has been implicated in the pathogenesis of ischaemic cardiovascular disease. In a series of clinical studies on male and female participants (NCT03946774 and NCT03994367) that involved graded amounts of protein ingestion together with detailed plasma amino acid analysis and human monocyte/macrophage experiments, we identify leucine as the key activator of mTOR signalling in macrophages. We describe a threshold effect of high protein intake and circulating leucine on monocytes/macrophages wherein only protein in excess of ∼25 g per meal induces mTOR activation and functional effects. By designing specific diets modified in protein and leucine content representative of the intake in the general population, we confirm this threshold effect in mouse models and find ingestion of protein in excess of ∼22% of dietary energy requirements drives atherosclerosis in male mice. These data demonstrate a mechanistic basis for the adverse impact of excessive dietary protein on cardiovascular risk.





  • Netomnia is a company that uses Openreach’s infrastructure (poles,ducts,manholes) to provide their own FTTP network. The cables and fibres they provide are ownred by them, but they lease the duct space from Openreach in order to get it from their own headend to a customers premises.

    There are dozens of these PIA companies all over the UK who have varying degrees of quality when it comes to building a network.

    I’ve not seen Netomnias build, but I have seen others like Airband and Full Fibre who are decent, to the other end of the scale like Virgin and Digital Infrastructure whose work is shocking to say the least.

    I personally have Airband and I’ve been very impressed with their price and service. If Netomnia offer a decent no strings package, it might be worth giving it a shot as Openreach or Virgin might not have plans to build in your area in the near future.

    Source: I work in the industry.